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S.E.M.I.: Side Effects May Include... cover art

S.E.M.I.: Side Effects May Include... release date

Out nowGamePC

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

Release date
November 20, 2025
Developer
Two Horn Unicorn
Publisher
Two Horn Unicorn
Genre
Hack and slash/Beat 'em up, Indie, Arcade

Where to buy

No store listings yet.

Out now

S.E.M.I.: Side Effects May Include... released on .

Release dates by platform and region

PlatformRegionDateUnlock timeStatusSource
PCWorldwideNot announcedReleasedSource

Release date history

  1. Date announced: November 20, 2025. Status: released — Upstream update (igdb) Source

Frequently asked questions

When does S.E.M.I.: Side Effects May Include... release?

S.E.M.I.: Side Effects May Include... released on November 20, 2025.

What time does S.E.M.I.: Side Effects May Include... unlock?

The exact unlock time has not been announced. Most digital releases unlock at midnight local time or at a single global time set by the publisher; this page will list it as soon as it is known.

Which platforms is S.E.M.I.: Side Effects May Include... on?

S.E.M.I.: Side Effects May Include... is releasing on PC.

Has S.E.M.I.: Side Effects May Include... been delayed?

No delay has been announced. This page tracks every date change with a source link.

Can I pre-order S.E.M.I.: Side Effects May Include...?

Pre-orders have not been listed yet. Stores and prices will appear here once available.